Plasma Thromboxane B_2 Concentration in Patients With Ventricular Septal Defect and Pulmonary Hypertension

• FUSE Shigeto

  Department of Pediatrics, Sapporo Medical University School of Medicine

• TOMITA Hideshi

  Department of Pediatrics, Sapporo Medical University School of Medicine

• CHIBA Shunzo

  Department of Pediatrics, Sapporo Medical University School of Medicine

抄録

Plasma thromboxane B_2 (TXB_2)-a stable metabolite of thromboxane A_2 (TXA_2)-conventional hemodynamic parameters, mean pulmonary input energy (input energy), and mean pulmonary output energy (output encrgy) were measured to assess platelet activation in 21 patients with pulmonary hypertension and a ventricular septal defect (VSD). The patients were divided into 2 groups: group A (normal range) and group B (high level). TXB_2 levels were measured by radioimmunoassay. There was no relationship between plasma TXB_2 concentrations and conventional hemodynamic parameters except the pulmonary-to-systemic pressure ratio. Output-to-input energy ratio was correlated logarithmically with the plasma TXB_2 concentration. We concluded that patients with output/input energy ratio >0.15 had a high TXB_2 concentration and activated platelets in pulmonary capillaries.

収録刊行物

• Japanese circulation journal

  Japanese circulation journal 62 (3), 193-197, 1998-02-20

  社団法人日本循環器学会

キーワード

• Cardiovascular disease
• Congenital heart defect
• Pulmonary hypertension
• Prostaglandins
• Thromboxane

詳細情報

• CRID: 1573950401964028416
• NII論文ID: 110002561165
• NII書誌ID: AA00690731
• ISSN: 00471828
• Web Site: https://search.jamas.or.jp/link/ui/1998163016
• 本文言語コード: en
• データソース種別:
  • CiNii Articles