Role of Platelets in Myocardial Ischemia-Reperfusion Injury in Dogs
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- SHIMADA Yoshifumi
- Third Department of Internal Medicine, Fukui Medical School
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- KUTSUMI Yasunori
- Third Department of Internal Medicine, Fukui Medical School
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- NISHIO Hiroyuki
- Third Department of Internal Medicine, Fukui Medical School
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- ASAZUMA Kenya
- Third Department of Internal Medicine, Fukui Medical School
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- TADA Hiroshi
- Third Department of Internal Medicine, Fukui Medical School
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- HAYASHI Takio
- Third Department of Internal Medicine, Fukui Medical School
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- NAKAI Tsuguhiko
- Third Department of Internal Medicine, Fukui Medical School
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- MORIOKA Koichi
- Second Department of Surgery, Fukui Medical School
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We investigated the involvement of circulating platelets in myocardial ischemia-reperfusion injury in canine autoperfused heart-lung preparations using filters to deplete platelets and/or leukocytes. The left anterior descending (LAD) coronary artery was occluded for 40 min, followed by 40 min raperfusion, in 3 groups: a leukocyte-platelet-depleted (LPD) group, in which both leukocytes and platelets were depicted; a leukocytedepleted (LD) group, in which leukocytes alone were depleted; and a control group. There were no differences in hemodynamics or arrhythmias among groups before or during coronary occlusion. After reperfusion, the maximum rate of change in left ventricular pressure during systole and diastole was significantly higher in the LPD group than in the control and LD groups. The LPD group also showed gradual recovery of regional myocardial function and a decrease in the frequency of premature ventricular contractions. The LD group showed a slight improvement in cardiac function and arrhythmias compared with the control group. Although there was no significant difference in the pulmonary arterial plasma level of thromboxane B_2 at any stage among groups, the control group showed an increase after reperfusion. These results suggest that platelets are important in reperfusion injury and that the depletion of both leukocytes and platelets effectively protects against reperfusion injury.
収録刊行物
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- Japanese circulation journal
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Japanese circulation journal 61 (3), 241-248, 1997-02-20
社団法人日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1572824502056563968
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- NII論文ID
- 110002564492
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- NII書誌ID
- AA00690731
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- ISSN
- 00471828
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles