L-Arginine Increases Exercise-Induced Vasodilation of the Forearm in Patients With Heart Failure

• KUBOTA Toru

  Research Institute of Angiocardiology and Cardiovascular Clinic,Faculty of Medicine,Kyushu University

• IMAIZUMI Tsutomu

  Research Institute of Angiocardiology and Cardiovascular Clinic,Faculty of Medicine,Kyushu University

• OYAMA Jun-ichi

  Research Institute of Angiocardiology and Cardiovascular Clinic,Faculty of Medicine,Kyushu University

• ANDO Shin-ichi

  Research Institute of Angiocardiology and Cardiovascular Clinic,Faculty of Medicine,Kyushu University

• TAKESHITA Akira

  Research Institute of Angiocardiology and Cardiovascular Clinic,Faculty of Medicine,Kyushu University

抄録

To determine whether L-arginine, a precursor of nitric oxide, can improve exercise-induced vasodilation of the forearm in patients with heart failure, we measured forearm blood flow in 9 patients with heart failure and in 7 age-matched control subjects before and after intra-arterial infusion of L-arginine. Resting forearm blood flow was significantly lower in patients with heart failure than in control subjects (2.34±0.85 (SD) vs 4.76±0.77 ml/min per 100 ml, p<0.001). Endothelium-dependent vasodilation induced by acetylcholine was attenuated in patients with heart failure (p<0.05). Exercise-induced vasodilation after handgrip exercise was significantly lower in patients with heart failure (p<0.05). Intra-arterial infusion of L-arginine did not change basal forearm blood flow but significantly augmented acetylcholine-induced vasodilation in both patients with heart failure and control subjects (p<0.05). Although L-arginine did not affect maximum forearm blood flow after handgrip exercise in control subjects (before, 26.2±13.5; after, 25.7±14.3; p=NS), it was increased in patients with heart failure (from 15.2±4.9 to 24.7±14.6, p<0.01). The finding that L-arginine increased both acetylcholine- and exercise-induced vasodilation in patients with heart failure suggests that endothelial dysfunction might play an important role in impaired exercise-induced vasodilation in patients with heart failure.

収録刊行物

• Japanese circulation journal

  Japanese circulation journal 61 (6), 471-480, 1997-05-20

  社団法人日本循環器学会

キーワード

• L-arginine
• Exercise
• Heart failure
• Forearm blood flow

詳細情報

• CRID: 1570572702242761216
• NII論文ID: 110002564524
• NII書誌ID: AA00690731
• ISSN: 00471828
• Web Site: https://search.jamas.or.jp/link/ui/1997221560
• 本文言語コード: en
• データソース種別:
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