Effect of the Initial Bolus Volume of Recombinant Tissue-Type Plasminogen Activator on Coronary Recanalization and Infarct Size in Japanese Acute Myocardial Infarction Patients

• OGAWA Hisao

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• YASUE Hirofumi

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• OSHIMA Shuichi

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• OGATA Yasuhiro

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• NUMATA Yuichi

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• FUJIMOTO Kinya

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• IMOTO Nobuya

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• SAITO Taro

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• HOKAMURA Youichi

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• TAKAHASHI Toru

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• WATANABE Hajime

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• KODAMA Hideaki

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• MORIKAMI Yasuhiro

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• MIYAGI Hiroo

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• OBATA Kenji

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• MATSUYAMA Koshi

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• SAKAINO Naritsugu

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• NAKAMURA Tomoki

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

• WAKITA Tomio

  the Kumamoto University Myocardial Infarction Study(KUMIS)Group

Abstract

Coronary recanalization rate and infarct size were compared between 2 different methods of intravenously administering recombinant tissue-type plasminogen activator(rt-PA)41.4mg; 1)an initial bolus dose of 30% followed by infusion of the remainder over 60 min(30% group), and an initial bolus dose of 10% followed by infusion of the remainder over 60 min(10% group). Thirty min after beginning rt-PA infusion, the coronary recanalization rate was higher in the 30% group than in the 10% group(82.9%(34/41)vs 53.7%(22/41), p<0.01). The peak creatine kinase and peak creatine kinase-MB levels were lower in the 30% group than in the 10% group. We conclude that a higher initial boulus dose of rt-PA gives a higher rate of recanalizaiton of the infarct-related artery at the very early phase, and probably leads to a smaller infarct size.

Journal

• Japanese circulation journal

  Japanese circulation journal 59 (10), 663-672, 1995-09-20

  Japanese Circulation Society

Keywords

• Recombinant tissue-type plasminogen activator
• Acute myocardial infarction
• Initial bolus volume
• Coronary recanalization
• Infarct size

Details

• CRID: 1570854177219612800
• NII Article ID: 110002564875
• NII Book ID: AA00690731
• ISSN: 00471828
• Web Site: https://search.jamas.or.jp/link/ui/1996133029
• Text Lang: en
• Data Source:
  • CiNii Articles