Improvement of Coronary Vasomotion With Eicosapentaenoic Acid Does Not Inhibit Acetylcholine-Induced Coronary Vasospasm in Patients With Variant Angina

20 References
  • YAMAMOTO Hideo
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital
  • YOSHIMURA Hitoshi
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital
  • NOMA Mitsuru
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital
  • SUZUKI Satoshi
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital
  • KAI Hisashi
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital
  • TAJIMI Tsukasa
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital
  • SUGIHARA Masayoshi
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital
  • KIKUCHI Yutaka
    Section of Cardiology, Department of Medicine, Kyushu Kosei Nenkin Hospital

Search this article

Abstract

Impaired function of the endothelium may be a mechanism of the coronary vasospasm induced by acetylcholine. We examined whether purified eicosapentaenoic acid (EPA), a major component of fish oil, improves the coronary vasomotion in response to acetylcholine, and the effect of purified EPA on acetylcholine (ACh)-induced coronary vasospasm in 22 patients with variant angina. ACh was infused into the coronary artery both before and after 4 months of EPA treatment (EPA 1.8 g/day, n=12). In the control group (n=10) that did not receive EPA, the response of the coronary diameter to ACh did not change over time. In the EPA-treated group, the cholinergic response in non-spastic sites changed from vasoconstriction to vasodilation, while ACh-induced coronary vasospasm persisted at the spastic sites. Therefore, EPA treatment improved the coronary vasomotor responsiveness to ACh, but did not inhibit ACh-induced coronary vasospasm.

Journal

References(20)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top