Prognostic Value of Iodine-123-Metaiodobenzylguanidine Imaging and Cardiac Natriuretic Peptide Levels in Patients With Left Ventricular Dysfunction Resulting From Cardiomyopathy

• Imamura Yoshihiro

  Department of Cardiology, Matsuyama Red Cross Hospital

• Fukuyama Takaya

  Department of Cardiology, Matsuyama Red Cross Hospital

• Mochizuki Teruhito

  Department of Cardiology, Matsuyama Red Cross Hospital

• Miyagawa Masao

  Department of Cardiology, Matsuyama Red Cross Hospital

• Watanabe Kouki

  Department of Cardiology, Matsuyama Red Cross Hospital

• on Behalf of the Ehime MIBG Heart Failure Study Investigators

  Department of Cardiology, Matsuyama Red Cross Hospital

抄録

This study assessed the prognostic value of Iodine-123-metaiodobenzylguanidine (MIBG) imaging and of the plasma level of cardiac natriuretic peptides in patients with left ventricular dysfunction resulting from cardiomyopathy. Predictors of cardiac death or hospitalization related to progressive heart failure were examined in 171 patients with chronic heart failure (96 patients with idiopathic cardiomyopathy and 75 patients with ischemic cardiomyopathy). All patients underwent MIBG imaging at rest and other hemodynamic studies. During a mean (±SD) follow-up period of 27±11 months, 11 patients died from heart failure and 16 required hospitalization. High MIBG washout was an independent predictor of cardiac death (relative risk [RR] = 1.158, p<0.0001) whereas the plasma level of brain natriuretic peptide (BNP: relative risk [RR] = 1.005, p<0.0001) and high MIBG washout (relative risk [RR] = 1.094, p<0.0001) were predictors of progressive heart failure (ie, combined cardiac death and hospitalization). Accelerated myocardial adrenergic nerve activity as assessed by MIBG imaging and the plasma levels of BNP are powerful predictors of the patient's prognosis. (Jpn Circ J 2001; 65: 155 - 160)

収録刊行物

• JAPANESE CIRCULATION JOURNAL

  JAPANESE CIRCULATION JOURNAL 65 (3), 155-160, 2001

  社団法人 日本循環器学会

キーワード

• Cardiac natriuretic
• Cardiomyopathy
• MIBG imaging
• Peptides
• Prognosis

詳細情報

• CRID: 1390001206434063616
• NII論文ID: 110002567011
• NII書誌ID: AA00690731
• DOI: 10.1253/jcj.65.155
• COI: 1:CAS:528:DC%2BD3MXitV2rurY%3D
• ISSN: 13474839
• ISSN: 00471828
• ISSN: http://id.crossref.org/issn/00471828
• PubMed: 11266187
• Web Site: https://search.jamas.or.jp/link/ui/2002036924
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可