The D Allele of the Angiotensin-Converting Enzyme Gene and Reperfusion-Induced Ventricular Arrhythmias in Patients With Acute Myocardial Infarction
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- Takezako Takanobu
- Department of Cardiology, Fukuoka University School of Medicine
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- Zhang Bo
- Department of Cardiology, Fukuoka University School of Medicine
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- Serikawa Takeshi
- Department of Cardiology, Fukuoka University School of Medicine
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- Fan Ping
- Department of Cardiology, Fukuoka University School of Medicine
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- Nomoto Junko
- Department of Cardiology, Fukuoka University School of Medicine
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- Saku Keijiro
- Department of Cardiology, Fukuoka University School of Medicine
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Abstract
The renin-angiotensin system may play a pivotal role in reperfusion ventricular arrhythmias (RVA). The purpose of this study was to investigate the association between angiotensin-converting enzyme (ACE) gene polymorphism and RVA in patients with acute myocardial infarction (AMI) in a case - control study. Patients who had undergone successful coronary intervention for AMI were enrolled (n=127, male/female: 97/30, mean age, 62.6 years). The incidence of RVA was continuously monitored by ECG at a coronary care unit. The severity of ventricular arrhythmias was evaluated in terms of the Lown's grade and patients with a high risk of ventricular arrhythmias that may cause sudden cardiac death (Lown's grade ≥2) within 5 h of coronary intervention were defined as cases (n=59), and otherwise as controls (n=68). A receiver operating characteristic curve was used to determine the discriminatory ability of continuous variables and to produce dummy variables for use in a logistic regression analysis. Cases had a significantly higher body mass index, higher maximal levels of serum creatine kinase, and a shorter time preceding coronary intervention than controls. The severity of coronary atherosclerosis was similar between the 2 groups. The frequency distribution of ACE genotypes in cases differed from that in controls (II/ID/DD: 22.0%/52.6%/25.4% vs 44.1%/41.4%/14.7%, p<0.05, by the Mantel-Haenzel chi-square test). The ACE-D allele had additive and dominant effects with regard to the occurrence of significant ventricular arrhythmias after adjusting for other risk factors. The ACE-D allele may play a pivotal role in sudden cardiac death in patients with AMI. (Jpn Circ J 2001; 65: 603 - 609)
Journal
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- Japanese Circulation Journal
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Japanese Circulation Journal 65 (7), 603-609, 2001
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390282681409397760
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- NII Article ID
- 110002568048
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- NII Book ID
- AA00690731
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- COI
- 1:CAS:528:DC%2BD3MXlt1Gls7k%3D
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- ISSN
- 13474839
- 00471828
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- PubMed
- 11446493
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed