Characterization of Anti-Myocardial Autoantibodies in Japanese Patients With Dilated Cardiomyopathy.
-
- Baba Akiyasu
- Department of Medicine, Kitasato Institute Hospital
-
- Yoshikawa Tsutomu
- Cardiology Division, Department of Medicine, Keio University School of Medicine
-
- Chino Masao
- National Hospital Tokyo Medical Center
-
- Murayama Akira
- Urawa Municipal Hospital
-
- Mitani Kazuhiko
- NKK Hospital
-
- Nakagawa Susumu
- Saiseikai Central Hospital
-
- Fujii Isao
- Cardiology Division, Department of Medicine, Keio University School of Medicine
-
- Shimada Megumi
- Cardiology Division, Department of Medicine, Keio University School of Medicine
-
- Akaishi Makoto
- Department of Medicine, Kitasato Institute Hospital
-
- Iwanaga Shiro
- Cardiology Division, Department of Medicine, Keio University School of Medicine
-
- Asakura Yasushi
- Cardiology Division, Department of Medicine, Keio University School of Medicine
-
- Fukuda Keiichi
- Cardiology Division, Department of Medicine, Keio University School of Medicine
-
- Mitamura Hideo
- Cardiology Division, Department of Medicine, Keio University School of Medicine
-
- Ogawa Satoshi
- Cardiology Division, Department of Medicine, Keio University School of Medicine
この論文をさがす
抄録
Few previous reports have comprehensively screened all the anti-myocardial autoantibodies (AMCA) in relation to other clinical profiles in patients with idiopathic dilated cardiomyopathy (IDC), so the present study used both immunohistochemistry (FITC) and immunoblotting (IB) for screening patients with IDC in order to characterize the clinical significance of AMCA. Sera were collected from 100 patients with IDC and age-matched 100 healthy control subjects (CTL). For FITC, an unfixed frozen section of human myocardium was used for the standard indirect immunofluorescence; for IB, total cardiac homogenates of the same myocardium were blotted to serum at 2 sets of dilution (1:200 and 1:10,000). The positive rates of AMCA detection for each method were as follows (IDC vs CTL); 39% vs 6% for FITC, 38% vs 4% for IB (1:200), and 10% vs 0% for IB (1:10,000). Fifty-nine patients with IDC and 8 CTL were positive for AMCA by either method, and 18 patients with IDC and 2 CTL were positive for AMCA by both methods. IB-positivity at 1:200 was an independent predictor by multiple logistic regression analysis of non-sustained ventricular tachycardias as well as left ventricular end-diastolic diameter and plasma norepinephrine concentration. (Jpn Circ J 2001; 65: 867 - 873)
収録刊行物
-
- JAPANESE CIRCULATION JOURNAL
-
JAPANESE CIRCULATION JOURNAL 65 (10), 867-873, 2001
社団法人 日本循環器学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681408921984
-
- NII論文ID
- 130004427757
- 110002568102
-
- NII書誌ID
- AA00690731
-
- COI
- 1:STN:280:DC%2BD3MrmsVejsQ%3D%3D
-
- ISSN
- 13474839
- 00471828
-
- PubMed
- 11665790
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可