Scintigraphic Evidence for a Specific Long-Chain Fatty Acid Transporting System Deficit and the Genetic Background in a Patient With Hypertrophic Cardiomyopathy
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- NAKATA Tomoaki
- Second Department of Internal Medicine(Cardiovascular Medicine),Sapporo Medical University School of Medicine
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- NAKAHARA Norifumi
- Second Department of Internal Medicine(Cardiovascular Medicine),Sapporo Medical University School of Medicine
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- SOHMIYA Koichi
- The Third Division,Department of Internal Medicine,Osaka Medical College
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- OAKAMOTO Fumio
- The Third Division,Department of Internal Medicine,Osaka Medical College
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- TANAKA Takao
- The Third Division,Department of Internal Medicine,Osaka Medical College
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- KAWAMURA Keishiro
- The Third Division,Department of Internal Medicine,Osaka Medical College
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- SHIMAMOTO Kazuaki
- Second Department of Internal Medicine(Cardiovascular Medicine),Sapporo Medical University School of Medicine
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抄録
The mechanism of cardiac uptake of long-chain free fatty acids has not been fully determined. We encountered a hypertrophic cardiomyopathy patient who showed a lack of cardiac uptake of 2 different types of long-chain fatty acid analogues on the scintigraphic images. Flow cytometric analysis revealed no platelet or monocyte CD36 molecule expression (type I CD36 deficiency) and his CD36 gene showed homozygous mutation for ^<478>C to T substitution, leading to an abnormal CD36 amino acid sequence. These findings strongly suggest that a specific transporting system rather than a simple diffusion is commonly involved in the cardiac uptake of long-chain free fatty acids in humans, and that the CD36 protein is the most likely candidate for the specific trans-porter and to explain scintigraphic defects on fatty acid imaging.
収録刊行物
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- Japanese circulation journal
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Japanese circulation journal 63 (4), 319-322, 1999-03-20
社団法人日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1571980077023971968
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- NII論文ID
- 110002572838
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- NII書誌ID
- AA00690731
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- ISSN
- 00471828
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles