Prognostic Value of Serum Hepatocyte Growth Factor in Patients With Acute Coronary Syndromes

• SATO Tetsuya

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

• YOSHINOUCHI Takeo

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

• SUGIMOTO Taro

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

• SAKAMOTO Taisuke

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

• FUJIEDA Hiroyuki

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

• MURAO Satoshi

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

• SATO Hirohiko

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

• OHE Tohru

  Department of Cardiovascular Medicine, Matsuyama Shimin Okayama University

抄録

The present study examined whether or not hepatocyte growth factor(HGF), an endothelium-specific growth factor that stimulates regeneration of the endothelium, is increased or has a prognostic significance in patients with acute coronary syndromes. HGF was measured in 106 patients with coronary artery disease(20stable effort angina, 12 unstable angina without adverse events, 24 unstable angina with adverse events and 50 acute myocardial infarction)on admission and 21 normal volunteers. The measurements in all patients were recorded before administration of heparin, and in acute myocardial infarction patients they were recorded from days 2 to 6 after heparin discontinuation on day 1. HGF levels(ng/ml)were 0.30±0.06 for the controls, 0.31±0.08 for stable effort angina patients, 0.31±0.08 for unstable angina patients without adverse evants, 0.40±0.20 for unstable angina patients with adverse events and inacute myocardial infarction patients they were 0.45±0.18 on day 0, 0.57±0.45 on day 2, 0.50±0.35 on day 3, 0.48±0.32 on day 4, 0.44±0.20 on day 5, and 0.38±0.14 on day 6. HGF plays a crucial role in the restoration of injured endothelial cells and is a predictor of adverse events in patients with acute coronary syndromes.

収録刊行物

• Japanese circulation journal

  Japanese circulation journal 63 (8), 583-588, 1999-07-20

  社団法人日本循環器学会

キーワード

• Acute coronary syndromes
• Adverse events
• Heparin
• Hepatocyte growth factor
• Prognostic value

詳細情報

• CRID: 1573950401860956288
• NII論文ID: 110002572858
• NII書誌ID: AA00690731
• ISSN: 00471828
• Web Site: https://search.jamas.or.jp/link/ui/1999253550
• 本文言語コード: en
• データソース種別:
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