KCl Inhibits Hypothalamic Activity to Attenuate Hypertension in DOCA-salt Rats : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

  • SASAKI SUSUMU
    The Second Department of Medicine Kyoto Prefectural University of Medicine
  • TAKEDA KAZUO
    The Second Department of Medicine Kyoto Prefectural University of Medicine
  • TAKAHASHI HAKUO
    The Second Department of Medicine Kyoto Prefectural University of Medicine
  • YONEDA SEIICHI
    The Second Department of Medicine Kyoto Prefectural University of Medicine
  • OKAJIMA HIROSHI
    The Second Department of Medicine Kyoto Prefectural University of Medicine
  • IYODA ISAO
    The Second Department of Medicine Kyoto Prefectural University of Medicine
  • YOSHIMURA MANABU
    The Second Department of Medicine Kyoto Prefectural University of Medicine
  • IJICHI HAMAO
    The Second Department of Medicine Kyoto Prefectural University of Medicine

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Potassium supplementation attenuated the development of hypertension in DOCA-salt rats but did not affect blood pressure in control rats. However, it caused a decrease in body weight in both groups of rats. Sympathetic nerve and pressor responses either to electrical stimulation of the hypothalamus or to intracisternal injections of hypertonic NaCl were enhanced in DOCA-salt rats but were normalized by KCl supplementation. Since the pressor responses to injected norepinephrine or tyramine remained unaltered by KCl treatment, a peripheral inhibition of cardiovascular reactivity was considered unlikely. Pretreatment with methyclothiazide also attenuated the elevation in blood pressure but did not affect the responsiveness to hypothalamic stimulation; hence increased natriuresis or diuresis alone could not account for the effects induced by KCl. These findings are consistent with the conclusion that KCl supplementation attenuates the development of DOCA-salt hypertension in rats by acting on the central nervous system to reduce sympathetic output.

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