Strategy to manage pump failure due to chronic pulmonary diseases, pathophysiology and treatment of right ventricular overload

• HANDA S

  Department of Medicine, School of Medicine, Keio University

• FUJII ISAO

  Department of Medicine, School of Medicine, Keio University

• OHONISHI SYOUHEI

  Department of Medicine, School of Medicine, Keio University

• YAMAZAKI HAJIME

  Department of Medicine, School of Medicine, Keio University

• NAKAMURA YOSHIRO

  Department of Medicine, School of Medicine, Keio University

抄録

The pathophysiology and treatment of pump failure with right ventricular overload due to chronic pulmonary diseases were discussed. When right ventricular overload occurs hypertrophy and dilatation of right ventricle follows and the heart as a whole, including left ventricle, is altered in morphology and function .Therapeutic measures for right ventricular overload are the key to management and treatment of pump failure. Pulmonary hypertension, as an etiological factor, is discussed and is divided into two categories, that is, mild to moderate pulmonary hypertension with hypoxia due to chronic obstructive lung disease, and severe pulmonary hypertension due to pulmonary vascular disease. In each category, effects of oxygen inhalation and vaso-dilating agents were evaluated. Oxygen did not decrease pulmonary vascular resistance in the state of chronic hypoxia, though a vasodilating agent was effective. In pulmonary vascular disease, vaso-dilating agents were effective to decrease pulmonary vascular resistance and pulmonary artery pressure, though the effect was less than 30% down in resistance.

収録刊行物

• Jpn Circ J

  Jpn Circ J 50 350-358, 1986

  社団法人日本循環器学会

キーワード

• Cor pulmonale
• Right ventricular overload
• Pump failure
• Vaso-ditating agent
• Pulmonary hypertension

詳細情報

• CRID: 1574231876876368000
• NII論文ID: 110002585383
• NII書誌ID: AA00690731
• ISSN: 00471828
• Web Site: https://search.jamas.or.jp/link/ui/1988103593
• 本文言語コード: en
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