PHOSPHATIDYLINOSITOL AND INOSITOLPHOSPHATIDE METABOLISM IN HYPERTROPHIED RAT HEART

• SHOKI MIKAKO

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• KAWAGUCHI HIDEAKI

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• OKAMOTO HIROSHI

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• SANO HITOSHI

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• SAWA HIROFUMI

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• KUDO TOSHIYUKI

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• HIRAO NORIFUMI

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• SAKATA YOSHIHITO

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• YASUDA HISAKAZU

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

抄録

The accumulation of both Inositol-(1,4,5)-trisphosphate (IP_3) and Inositol-(1,3,4,5)-tetrakisphosphate (IP_4) after hormonal stimulation has a physiological role, possibly in altering Ca^<2+> levels in cardiac tissue. However, the accumulation of inositol polyphosphate under pathophysiological conditions has not been studied. In our experiments the metabolism of phatidylinositol and IP_3 m cardiac myocytes as investigated. It was shown that basal levels of cytosolic phosphatidylinositol specific phospholipase C (PI-PLC), phosphatidylinositol-(4,5)-bisphosphate specific phospholipase C (PIP_2-PLC) activities markedly increased in stroke-prone spontaneously hypertensive rats (SHRSP) with age compared with age matched Wistar Kyoto rats (WKY). IP_3 kinase and IP_3 phosphatase activities also increased in SHRSP hearts with age. Their activities increased in WKY, but to a lesser antent than in SHRSPs. These data suggest that a PI turnover pathway such as the phosphatidylinositol 4,5-bisphosphate-IP_3-Ca^<2+> pathway or the diacylglyceride-protein kinase C pathway may have an important role in the development of hypertrophy in SHRSP heart.

収録刊行物

• Japanese circulation journal

  Japanese circulation journal 56 (2), 142-147, 1992-02-20

  社団法人日本循環器学会

キーワード

• Phosphatidylinositides-specific phospholipase C
• Inositol-(1,4,5)-trisphosphate
• Inositol triphosphate kinase
• Inositol trisphosphate phosphatase

詳細情報

• CRID: 1571980077062271872
• NII論文ID: 110002587458
• NII書誌ID: AA00690731
• ISSN: 00471828
• Web Site: https://search.jamas.or.jp/link/ui/1993070131
• 本文言語コード: en
• データソース種別:
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