Endothelium-Derived Hyperpolarizing Factor (EDHF).

• SUZUKI HIKARU

• CHEN GUIFA

• YAMAMOTO YOSHIMICHI

抄録

In vascular tissues, many types of stimulants which release endothelium-derived relaxing factor (EDRF) hyperpolarized the smooth muscle membrane in an endothelium-dependent manner. The hyperpolarizations were resistant to inhibitors of the actions of EDRF, thereby suggesting that they were elicited by an unidentified substance called endothelium-derived hyperpolarizing factor (EDHF). The EDHF induced hyperpolarization was produced by an increase in K⁺-permeability of the membrane, and was one of the factors to induce endothelium-dependent vasodilations. Release of EDHF required an increase in endothelial Ca<2+>, due eithr to release of Ca<2+> from intracellular storage or to its influx from the external media.

収録刊行物

• JAPANESE CIRCULATION JOURNAL

  JAPANESE CIRCULATION JOURNAL 56 (2), 170-174, 1992

  社団法人 日本循環器学会

キーワード

• Endothelium
• Hyperpolarization
• Vascular smooth muscle
• Relaxation
• K-permeability

詳細情報

• CRID: 1390001206431001088
• NII論文ID: 110002587463
• NII書誌ID: AA00690731
• DOI: 10.1253/jcj.56.170
• COI: 1:CAS:528:DyaK38XktVCqu7k%3D
• ISSN: 13474839
• ISSN: 00471828
• PubMed: 1548837
• Web Site: http://www.jstage.jst.go.jp/article/circj1960/56/2/56_2_170/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1993103481
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可