Dynamic process between the clottin and the lytic activities on intracardiac thrombi : Its relationship with systemic embolization.
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- UMEMOTO K.
- The Department of Internal Medicine, Kansai Rosai Hospital
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- FUKUNAMI MASATAKE
- Division of Cardiology, Osaka Prefectural Hospital
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- OHMORI MASAHARU
- Division of Cardiology, Osaka Prefectural Hospital
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- KUMAGAI KAZUAKI
- Division of Cardiology, Osaka Prefectural Hospital
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- SAKAI AKIHIKO
- Division of Cardiology, Osaka Prefectural Hospital
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- YAMADA TAKAHISA
- Division of Cardiology, Osaka Prefectural Hospital
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- KONDOH NOBUHIKO
- Division of Cardiology, Osaka Prefectural Hospital
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- MINAMINO TETSUO
- Division of Cardiology, Osaka Prefectural Hospital
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- TSUJIMURA EIITIROH
- Division of Cardiology, Osaka Prefectural Hospital
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- HOKI NORITAKE
- Division of Cardiology, Osaka Prefectural Hospital
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To clarify the relationship between clotting and lytic activities of intracardiac thrombi, and to elucidate whether this could be used to evaluate the embolic risk the ratio of indium-111 radioactivity accumulated on thrombi to that in the blood pool using dual-tracer technique %IE as a parameter of the clotting activity, and D-dimer, which is a fibrin specific degradation product, as a parameter of lytic activity were measured in 37 patients with intracardiac thrombi. Fifteen of the 37 patients had past histories of arterial embolization. The values of D-dimer correlated significantly with those of %IE (r=0.758, p<0.01), e,g., the higher the values of D-dimer the higher the values of %IE. 37 patients were divided into 2 groups using the regression line for the D-dimer and %IE domains. Eleven patients above the regression line had thrombosis in excess of fibrinolysis but the remaining 26 patients under the regression line had fibrinolysis in excess of thrombosis. The incidence of past embolic episodes was 82% (9/11) in patients with thrombosis in excess of fibrinolysis but 23% (6/26) in patients with fibrinolysis in excess of thrombosis. These results demonstrated that intracardiac thrombi were under the dynamic process between the clotting and the lytic activities and moreover patients with intracardiac thrombi and thrombosis in excess of fibrinolysis had a substantial risk of arterial embolization.
収録刊行物
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- Jpn Circ J
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Jpn Circ J 56 793-800, 1992
社団法人日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1572543027017432064
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- NII論文ID
- 110002587551
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- NII書誌ID
- AA00690731
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- ISSN
- 00471828
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles