Cardioprotective Effect of Mexiletine in Acute Myocardial Ischemia. Studies in the Rabbit Closed Chest Ischemia Model.

• Inuo Kimiatsu

  Department of Internal Medicine, Kitasato University School of Medicine

• Niwano Shinichi

  Department of Internal Medicine, Kitasato University School of Medicine

• Morohoshi Yasuo

  Department of Laboratory Animal Science, Kitasato University School of Medicine

• Nakayama Shigenobu

  Department of Laboratory Animal Science, Kitasato University School of Medicine

• Ikeda Kazuko

  Department of Internal Medicine, Kitasato University School of Medicine

• Kojima Jisyou

  Department of Internal Medicine, Kitasato University School of Medicine

• Saito Junko

  Department of Internal Medicine, Kitasato University School of Medicine

• Masuda Takashi

  Department of Internal Medicine, Kitasato University School of Medicine

• Izumi Tohru

  Department of Internal Medicine, Kitasato University School of Medicine

書誌事項

タイトル別名

• Studies in the Rabbit Closed Chest Ischemia Model

抄録

ATP-sensitive K⁺ (K_ATP) channel openers have a cardioprotective effect and so mexiletine (Mex), a class Ib anti-arrhythmic drug, may also be cardioprotective because of its K_ATP channel-opening effect. The present study examined the effect of Mex on acute myocardial ischemia in a closed-chest acute ischemia and reperfusion model in rabbits. The rabbits were divided into 3 groups: (1) control (n=8); (2) Mex (n=8), continuous infusion of mexiletine (24 mg · kg ^-1 · h^-1); and (3) Mex + Gli (n=8), pre-administration of glibenclamide (Gli; 0.5 mg/kg) followed by mexiletine infusion. The incidence of arrhythmia, the hemodynamics and left ventricular ejection fraction (LVEF), and the infarct size were evaluated and compared among the 3 groups. The incidence of fatal ventricular fibrillation (VF) was least in the Mex group. The LVEF at 30 min after reperfusion was least in the Mex group, but at 360 min after reperfusion, it was least in the Mex + Gli group. The area of myocardial infarction determined by 2,3-triphenyltetrazolium chloride (TTC) staining was smallest in the Mex group. In this model, Mex reduced infarct size and improved left ventricular function during the late phase after reperfusion, although the effect was totally negated by the addition of glibenclamide. (Circ J 2002; 66: 403 - 410)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 66 (4), 403-410, 2002

  一般社団法人 日本循環器学会

キーワード

• Cardiac ischemia
• Cardioprotective effect
• Glibenclamide
• K_ATP channel
• Mexiletine

詳細情報

• CRID: 1390282680081496832
• NII論文ID: 110002587631
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.66.403
• COI: 1:CAS:528:DC%2BD38XjtVChurw%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 11954958
• Web Site: http://www.jstage.jst.go.jp/article/circj/66/4/66_4_403/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002199476
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可