Influence of arotinolol hydrochloride on heart rate spectrum in hypertensive subjects

1 Citations
  • HARASAWA Y.
    The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University
  • IMAIZUMI TSUTOMU
    The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University
  • ANDO SHIN-ICHI
    The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University
  • MASAKI HIROYUKI
    The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University
  • HARADA SEIKI
    The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University
  • MOMOHARA MICHIKO
    The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University
  • TAKESHITA AKIRA
    The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovascular Clinic, School of Medicine, Kyushu University

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Abstract

Influence of arotinolol hydrochloride and atenolol on the balance between the sympathetic and parasympathetic nervous systems was evaluated in 8 hypertensive subjects by spectral analysis of heart rate (HR) and systemic blood pressure (BP). Before and after administration of either arotinolol (n=7) or atenolol (n=7) for 2 weeks, BP was continuously and non-invasively monitored by a finger-cuff manometry (Finapres) . A time series of instantaneous HR was constructed from the BP signal. A time series of mean BP was also constructed. Spectral analysis was performed by the use of an autoregressive algorithm on these time series (〜180 sec). Each spectrum was subdivided into low-(0.05-0.15 Hz, LF) and high-frequency (0.15-0.4 Hz, HF) components, and each component was divided by the sum of the two for normalization. As a measure of the balance between the sympathetic and parasympathetic nervous systems, the ratio of LF to HF (LF/HF) was evaluated. Arotinolol increased fractional HF in the HR spectrum from 0.45±0.12 to 0.73±0.08 (p<0.01) and decreased fractional LF from 0.55±0.12 to 0.27±0.08 (p<0.01); consequently, it decreased LF/HF from 1.4±0.5 to 0.4±0.2 (p<0.01). Atenolol had similar effects on these parameters. Neither of these β-adrenergic blockades produced a discernible decrease in LF/HF in the BP spectrum. In conclusion, these β -adrenergic blockades decreased LF/HF in the HR spectrum in hypertensive subjects, which suggests that they improved the balance between the sympathetic and parasympathetic nervous systems.

Journal

  • Jpn Circ J

    Jpn Circ J 58 326-337, 1994

    Japanese Circulation Society

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