Pathophysiology and pathogenesis of contractile failure in stunned myocardium

被引用文献1件
  • KUSUOKA H.
    The First Department of Medicine, Osaka University Medical School
  • KITAKAZE MASAFUMI
    The First Department of Medicine, Osaka University Medical School
  • KORETSUNE YUKIHIRO
    The First Department of Medicine, Osaka University Medical School
  • INOUE MICHITOSHI
    Department of Medical Information Science, Osaka University Hospital
  • MARBAN EDUARDO
    Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, U.S.A.

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抄録

To investigate excitation-contraction coupling in stunned myocardium, intracellular free calcium concentration ([Ca^<2+>]_i) was measured before and after ischemia in perfused hearts using gated ^<19>F NMR and the Ca^<2+> indicator 5F-BAPTA. Maximal Ca^<2+>-activated force was also measured in parallel experiments. Stunned myocardium was created by reperfusion after 15 min global ischemia at 37℃ in isolated ferret hearts. In stunned myocardium, peak [Ca^<2+>]_i was paradoxically higher than that in control, but maximal Ca^<2+>-activated pressure was lower in stunned hearts. These results indicate that contractile failure in stunned myocardium is due to a decrease in the myofilament sensitivity to Ca^<2+> as well as to a decrease in maximal Ca^<2+>-activated force; failure of activator Ca^<2+> delivery cannot be implicated. The role of intracellular calcium overload in the pathogenesis of stunned myocardium was also investigated. Time-averaged ^<19>F NMR measutements directly revealed the increase in [Ca^<2+>]_i during ischemia and in the early phase of reperfusion. The strategies to prevent Ca overload during reperfusion with modified reperfusate succeeded in preserving contractile function. Transient Ca overload without ischemia induced by different causes, i.e., high [Ca]_0 perfusion, ventricular fibrillation or treatment with adriamycin, also produced contractile dysfunction that outlasted the interventions themselves. Thus, we propose that transient Ca overload during ischemia and early reperfusion initiates long-lasting contractile dysfunction in stunned myocardium.

収録刊行物

  • Jpn Circ J

    Jpn Circ J 55 878-884, 1991

    社団法人日本循環器学会

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