EVALUATION OF INTRAVASCULAR HEMOLYSIS BY HAPTOGLOBIN ADMINISTRATION AFTER PROSTHETIC VALVE REPLACEMENT SHIOI KENSUKE NAGATA YOSHIHISA MASE TAKENORI AOYAMA TAKAHIKO KATOH SHINJI TSUCHIOKA HIROMICHI 社団法人日本循環器学会 Japanese circulation journal 00471828 57 4 322 327 1993-04-20 Although the measurement of serum haptoglobin (S-Hp) is of great use for evaluation of intravascular hemolysis, it is not applicable in patients with mechanical prosthetic valves because S-Hp is virtually absent. We administered haptoglobin preparation to 10 patients with Bjork-Shiley mitral prosthetic valves and 10 patients with the same aortic prosthetic valves. Serum haptoglobin levels were measured periodically afterwards. The maximum haptoglobin levels (Hp (max)), serum, haptoglobin reducing rate ((Hp-ΔHp)/ Δt) and expected haptoglobin disappering time (hours) were obtained from the subsequent samples. The screening studies which were performed at the same time were not predictors of difference in the 2 groups. On the other hand, serum haptoglobin reducing rate and expected haptoglobin disappearing time indicated that hemolysis is higher in patients with an aortic prosthetic valve than with a mitral prosthetic valve. This haptoglobin administration test seems to be useful for the comparative examination of the intravascular hemolysis caused by the difference in the position of the prosthetic valve. 1993-04-20 110002595777 AA00690731 ENG NII-ELS 3 EVALUATION OF INTRAVASCULAR HEMOLYSIS BY HAPTOGLOBIN ADMINISTRATION AFTER PROSTHETIC VALVE REPLACEMENT SHIOI KENSUKE NAGATA YOSHIHISA MASE TAKENORI AOYAMA TAKAHIKO KATOH SHINJI TSUCHIOKA HIROMICHI Japanese Circulation Society Japanese circulation journal Although the measurement of serum haptoglobin (S-Hp) is of great use for evaluation of intravascular hemolysis, it is not applicable in patients with mechanical prosthetic valves because S-Hp is virtually absent. We administered haptoglobin preparation to 10 patients with Bjork-Shiley mitral prosthetic valves and 10 patients with the same aortic prosthetic valves. Serum haptoglobin levels were measured periodically afterwards. The maximum haptoglobin levels (Hp (max)), serum, haptoglobin reducing rate ((Hp-ΔHp)/ Δt) and expected haptoglobin disappering time (hours) were obtained from the subsequent samples. The screening studies which were performed at the same time were not predictors of difference in the 2 groups. On the other hand, serum haptoglobin reducing rate and expected haptoglobin disappearing time indicated that hemolysis is higher in patients with an aortic prosthetic valve than with a mitral prosthetic valve. This haptoglobin administration test seems to be useful for the comparative examination of the intravascular hemolysis caused by the difference in the position of the prosthetic valve. SHIOI KENSUKE The Second Department of Surgery, Aichi Medical University NAGATA YOSHIHISA The Second Department of Surgery, Aichi Medical University MASE TAKENORI The Second Department of Surgery, Aichi Medical University AOYAMA TAKAHIKO The Second Department of Surgery, Aichi Medical University KATOH SHINJI The Second Department of Surgery, Aichi Medical University TSUCHIOKA HIROMICHI The Second Department of Surgery, Aichi Medical University