肺減圧反射に関する研究 : 肺小血管領域における受容体の存在について

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  • Studies on Pulmonary Depressor Reflex, with Special Reference to Mechano-Receptor Distribution in the Small Pulmonary : Vasculature including Pulmonary Capillary Bed
  • ハイ ゲンアツ ハンシャ ニ カンスル ケンキュウ ハイ ショウケッカン リョウイキ ニ オケル ジュヨウタイ ノ ソンザイ ニ ツイテ

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The response, systemic hypotension and bradycardia, provoked by elevating Intravascular pressure (IVP) in the lung lobe, whose perfusion was separated from the pulmonary circulation in situ, was described as "pulmonary depressor reflex" by Schwiegk, 1935. Although mechanism of the reflex has not been entirely disclosed yet, it Is generally approved that the vagus is the main pathway, both afferent and efferent, connected to the center. Regarding location of mechanoreceptor in the pulmonary vascular tree, however, it is still controversial whether the receptor lies in the pulmonary artery or in the pulmonary vein system. Moreover, there has been few description in regard to receptors in the small pulmonary vessels including capillary bed, until present time. Recently, Salisbury et al. and Daly. M. et al. discussed that inflation of the lung lobe also showed the similar systemic hypotension and bradycardia. Nowadays, a quotion has been raised whether the mechano-receptors in the pulmonary vascular tree, which must be affected by deformation of the lung, could be considered to be comparable to the stretch receptors in the lung parenchyma. Following experiments were designed in the hope to throw a light on the above mentioned enigmatical pulmonary mechano-receptors. Methods Twenty-eight adult mongrel dogs were anesthetized with pentobarbital soda (25mg/kg, i.v.) and thoracotomy was carried out in the fourth intercostal space under positive pressure ventilation. Both the pulmonary artery (PA) and vein (PV) of the left lower lobe (LLL) were ligated and cannulated immediately distal to the ligation, for the purpose of rapid infusion with autologus heparinized blood and measurement of IVP. Ventilation of LLL was also separated from the other lung lobes by means of a small specially devised cuffed tube passed through the main tracheal tube. LLL was inflated with the gas mixture consisting of 5.6% CO2, 14% O2, and N2, as required in the course of the experiment. A free margin of LLL was stretched or corn-pressed slightly by using the finger tips with special care in order not to pull the hilus. The same procedures were carried out also in the ipsilaterally or bilaterally vagotomized dogs. After PA or PV embolization with Lycopodiurn spores, infusion with a high pressure of the embolized lobar vessel initially, then the similar infusion of the non-embolized one was performed.

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