Studies on the Turnover of Myocardial Actomyosin in Dogs with Experimental Aortic Insufficiency and the Effect of Vitamin B_<12> on Actomyosin Metabolism

  • YOKOTA YASUSHI
    The Third Department of Internal Medicine, Kurume University School of Medicine

この論文をさがす

抄録

The turnover rate of actomyosin of myocardium and skeletal muscle was studied in control dogs and in those with experimentally produced aortic insufficiency. Based on the concept that vitamin B_<12> is an activating drug for myocardial metabolism, a large dose of it was given some of the dogs with aortic insufficiency to study the effect of vitamin B_<12> on the turnover of actomyosin in the overloaded heart. During the early period, when there was an acute increase in the load on the heart, the turnover rate of myocardial actomyosin in the dogs with aortic insufficiency increased and that of dogs administrated vitamin B_<12> increased remark-ably. However, during a relatively stable period (from 9th-30th day after production of aortic insufficiency), the turnover rate of myocardial actomyosin in both dogs with aortic insufficiency and those administrated vitamin B_12, approached control levels. From these observations it seems that increase in turnover rate is an important compensatory factor in the diastolic-overloaded heart and administration of vitamin B_12 is useful in treatment of the overloaded heart.

収録刊行物

詳細情報

  • CRID
    1570009752300178560
  • NII論文ID
    110002610410
  • NII書誌ID
    AA00690731
  • ISSN
    00471828
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

問題の指摘

ページトップへ