Effects of alpha human atrial natriuretic polypeptide on the systemic hemodynamics and coronary circulation in patients with ischemic heart disease
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- SERIZAWA T
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- KOHMOTO OSAMI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- IIZUKA MASAHIKO
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- HIRATA YASUNOBU
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- MATSUOKA HIROAKI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- OHYA TETSUO
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- KIMURA YOSHIO
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- SATO HIROAKI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- TAKAHASHI TOSHIYUKI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- MASUO MASATOSHI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- MOCIHZUKI TAKATOSHI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- ISHII MASAO
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- SUGIMOTO TSUNEAKI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- KANGAWA KENJI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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- MATSUO HISAYUKI
- The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo The Second Department of Biochemistry, Miyazaki Medical College
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抄録
Alpha human atrial natriuretic polypeptide (α-hANP) was intravenously infused into 7 patients with ischemic heart disease who had almost normal cardiac function at a rate of 0.025 μg/kg/min for 15 min. During infusion of α-hANP, left ventricular (LV) systolic pressure decreased from 144 ± 19 (SD) to 129 ± 22 mmHg (p < 0.01), LV end diastolic pressure (EDP) from 15 ± 5 to 13 ± 4 mmHg (p < 0.05), mean aortic pressure from 102 ± 14 to 91 ± 14 mmHg (p < 0.01), time constant of LV pressure fall (T) from 100 ± 15 to 88 ± 13 msec (p < 0.05), systemic vascular resistance (SVR) from 1711 ± 206 to 1424 ± 340 dynes・sec・cm^<-5> (p < 0.05) and coronary vascular resistance (CVR) from 8.5 ± 1.2 to 7.4 ± 1.3 × 10^4 dynes・sec・cm^<-5> (p < 0.05). There was a linear correlation between percent changes in SVR and those of CVR (r=0.92, p < 0.01), and the fall in CVR was approximately 68% of that in SVR. Increases occurred in heart rate from 63 ± 7 to 66 ± 8 beats/min (p < 0.05), LV dp/dt from 1558 266 to 1627 238 mmHg/sec (p 0.05), LV dp/dt/p from 22.9 3.2 to 25.6 3.7/sec (p 0.01), and myocardial oxygen consumption (from 7.9 2.4 to 9.8 2.1 ml/min, p 0.05), while mean right atrial and mean pulmonary arterial pressures and pulmonary vascular resistance were unchanged. -hANP dilates the systemic and coronary resistance vessels, and increases myocardial shortening velocity and relaxation.
収録刊行物
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- Jpn Circ J
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Jpn Circ J 52 1107-1113, 1988
社団法人日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1571135652138051968
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- NII論文ID
- 110002630838
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- NII書誌ID
- AA00690731
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- ISSN
- 00471828
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles