Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees: a case–control study

• Nakamura Tadashi

  Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

• Tsubono Yoshitaka

  Department of Public Health, Tohoku University, School of Medicine

• Kameda-Takemura Kaoru

  Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

• Funahashi Tohru

  Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

• Yamashita Shizuya

  Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

• Hisamichi Shigeru

  Department of Public Health, Tohoku University, School of Medicine

• Kita Toru

  Department of Molecular Medicine for Adult and Geriatric Diseases, Graduate School of Medicine, Kyoto University

• Yamamura Taku

  Department of Etiology, Research Institute of National Cardiovascular Center

• Matsuzawa Yuji

  Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

• The Group of the Research for the Association between Host Origin and Atherosclerotic Diseases under the Preventive Measure for Work-related Diseases of the Japanese Labor Ministry

書誌事項

タイトル別名

• Magnitude of Sustained Multiple Risk Factors for Ischemic Heart Disease in Japanese Employees
• A Case-Control Study

抄録

A case - control study was performed to clarify the cause of ischemic heart disease (IHD), such as acute myocardial infarction and angina pectoris, in Japanese employees. Among 122,051 workers from 31 industries, 94 cases of IHD were the subjects of the study, and a total of 191 age-matched subjects from the same department, but who did not develop IHD, served as the controls. Compared with the control group, body mass index, blood pressure, fasting plasma glucose, serum total cholesterol and serum triglyceride were significantly higher, and cigarette consumption and serum uric acid also tended to be higher, in the patient group from at least 10 years prior to onset. The frequency of moderate-drinkers tended to be lower in the case group. Electrocardiograms showed that, compared with the control group, the frequency of myocardial ischemia was higher in the case group from 9 years prior to onset and further rapidly increased from 3 years prior. The frequency of subjects with arrhythmia was the same as the control group until 3 years before onset and increased rapidly from 2 years prior. The frequency of subjects with multiple risk factors, particularly obesity, hypertension, hyperlipidemia and hyperglycemia, was consistently higher in the case group compared with the control group from 10 years prior to onset. Conditional logistic regression analysis demonstrated that having more than one risk factor greatly increased the risk; in particular, the combination of 3 or more factors increased the relative risk to 10.56 (95% confidence interval: 3.30-33.78). These findings suggest that a long duration of multiple risks is involved in the onset of IHD in Japanese employees, and that annual ECG monitoring as part of the medical examination was important in the prognosis. (Jpn Circ J 2001; 65: 11 - 17)

収録刊行物

• JAPANESE CIRCULATION JOURNAL

  JAPANESE CIRCULATION JOURNAL 65 (1), 11-17, 2001

  社団法人 日本循環器学会

キーワード

• Case - control study
• Electrocardiogram
• Industries
• Ischemic heart disease
• Multiple risk factors

詳細情報

• CRID: 1390001206433255424
• NII論文ID: 110002635339
• NII書誌ID: AA00690731
• DOI: 10.1253/jcj.65.11
• COI: 1:STN:280:DC%2BD3M3ls1CktA%3D%3D
• ISSN: 13474839
• ISSN: 00471828
• ISSN: http://id.crossref.org/issn/13469843
• ISSN: http://id.crossref.org/issn/00471828
• PubMed: 11153815
• Web Site: https://search.jamas.or.jp/link/ui/2002035094
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可