Significance of Monocyte Chemotactic Protein-1 and Thymidine Phosphorylase in Angiogenesis of Human Cardiac Myxoma.

• Zhang Tianshu

  Second Department of Surgery, Shinshu University School of Medicine

• Koide Naohiko

  Second Department of Surgery, Shinshu University School of Medicine

• Wada Yuko

  Second Department of Surgery, Shinshu University School of Medicine

• Tsukioka Katsuaki

  Second Department of Surgery, Shinshu University School of Medicine

• Takayama Kei

  Second Department of Surgery, Shinshu University School of Medicine

• Kono Tetsuya

  Second Department of Surgery, Shinshu University School of Medicine

• Kitahara Hiroto

  Second Department of Surgery, Shinshu University School of Medicine

• Amano Jun

  Second Department of Surgery, Shinshu University School of Medicine

抄録

Angiogenesis is indispensable to tumor development and proliferation. The aim of this study was to investigate whether the expression of monocyte chemotactic protein-1 (MCP-1) and of thymidine phosphorylase (TP) correlates with the angiogenesis and clinicopathologic features in cardiac myxoma. Paraffin-embedded specimens of 17 resected cardiac myxomas were immunohistochemically stained for MCP-1, CC chemokine receptor-2 (CCR-2), TP, CD31, and CD68. Correlations among MCP-1 expression, TP expression, microvessel count (determined by CD31 staining), macrophage count (determined by CD68 staining), and the clinicopathologic features of the patients were analyzed statistically. Immunohistochemical analysis revealed that MCP-1 and TP were expressed in myxoma cells, as well as in stromal cells such as infiltrating cells, fibroblast-like cells and endothelial cells. CCR-2 was abundantly expressed in stromal infiltrating cells in all myxomas and occasionally in the endothelial cells. In the tumor stroma, the major source of MCP-1, TP and CCR-2 was macrophages, and the sites of positive staining for MCP-1, TP and CCR-2 matched in most of the myxomas. Statistical analysis revealed that the proportions of MCP-1-positive myxoma and stromal cells, and TP-positive myxoma and stromal cells significantly correlated with increased microvessel count. The proportions of MCP-1-positive myxoma and stromal cells significantly correlated with the proportion of TP-positive stromal cells. The mean microvessel count in myxomas with both high tumor and high stromal MCP-1 or TP expression was significantly higher than that in myxomas with low tumor and low stromal MCP-1 or TP expression. Small tumors (≤55 mm in diameter) exhibited high MCP-1 or TP expression, and the microvessel count in small tumors was significantly higher than in large myxomas. Although the difference was not significant, myxomas with both high tumor and high stromal MCP-1 expression had a higher macrophage count than other myxomas. These results indicate that in cardiac myxoma, MCP-1 and TP may be regarded as important angiogenic signals accompanying growth. (Circ J 2003; 67: 54 - 60)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 67 (1), 54-60, 2003

  一般社団法人 日本循環器学会

キーワード

• Angiogenesis
• Cardiac myxoma
• CC chemokine receptor-2
• Monocyte chemotactic protein-1
• Thymidine phosphorylase

詳細情報

• CRID: 1390001205104078848
• NII論文ID: 110002666209
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.67.54
• COI: 1:CAS:528:DC%2BD3sXlt1Sluw%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 12520153
• Web Site: http://www.jstage.jst.go.jp/article/circj/67/1/67_1_54/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003147986
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可