Supersensitive Response to Isoproterenol in Patients With Marked Global Reduction of Cardiac Metaiodobenzylguanidine Uptake

• Yoshida Naohiro

  The Second Department of Internal Medicine

• Nozawa Takashi

  The Second Department of Internal Medicine

• Nonomura Makoto

  The Second Department of Internal Medicine

• Igarashi Norio

  The Second Department of Internal Medicine

• Kato Bun-ichi

  The Second Department of Internal Medicine

• Fujii Nozomu

  The Second Department of Internal Medicine

• Igawa Akihiko

  The Second Department of Internal Medicine

• Asanoi Hidetsugu

  The Second Department of Internal Medicine

• Seto Hikaru

  Department of Radiology, Toyama Medical and Pharmaceutical University

• Inoue Hiroshi

  The Second Department of Internal Medicine

抄録

It is unknown whether the non-transplanted, denervated human heart is supersensitive to β-adrenergic agonist in terms of inotropism and chronotropism. In the present study, 36 patients with normal left ventricular (LV) wall motion were divided into 3 groups according to the cardiac metaiodobenzylguanidine (MIBG) scintigrams: group I with normal MIBG uptake, group II with regionally reduced MIBG uptake, and group III with globally reduced MIBG uptake (heart-to-mediastinum ratio <1.6). Before isoproterenol (IP) infusion, heart rate (HR), blood pressure (BP) and echocardiographic indices were similar among the groups. There was a trend toward a greater increase in HR with IP (0.01 μg · kg ^-1 · min^-1) in group III (27±18 beats/min) than in groups I (20±8) and II (17±8) despite the lack of a significant difference in BP reduction by IP. During IP infusion, increases in posterior wall motion amplitude and LV fractional shortening were significantly greater in group III (4.5±1.8 mm and 16.4±5.4%, respectively) than in groups I (1.5±2.5 mm and 8.7±6.4%) and II (2.6±1.7 mm and 8.9±7.9%). The present results suggest that the sympathetically denervated human heart is supersensitive to IP and the exaggerated responses may be caused, at least in part, by a postsynaptic mechanism. (Circ J 2003; 67: 745 - 749)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 67 (9), 745-749, 2003

  一般社団法人 日本循環器学会

キーワード

• b-agonist
• Cardiac denervation
• Supersensitivity
• Sympathetic nerve

詳細情報

• CRID: 1390001205104185728
• NII論文ID: 110002666395
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.67.745
• COI: 1:STN:280:DC%2BD3svhs1ChtA%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 12939548
• Web Site: http://www.jstage.jst.go.jp/article/circj/67/9/67_9_745/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004020106
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可