Myocardial Glucose Metabolism Assessed by Positron Emission Tomography and the Histopathologic Findings of Microvessels in Syndrome X
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- Satake Osamichi
- Departments of Cardiology, Kanazawa Medical University
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- Kajinami Kouji
- Departments of Cardiology, Kanazawa Medical University
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- Ishikawa Yoshimaro
- Pathology (II), Kanazawa Medical University
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- Ueda Tadashi
- Anatomy, Kanazawa Medical University
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- Tsugawa Hiroichi
- Departments of Cardiology, Kanazawa Medical University
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- Kanemitsu Seiyu
- Departments of Cardiology, Kanazawa Medical University
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- Okubo Shinji
- Departments of Cardiology, Kanazawa Medical University
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- Takekoshi Noboru
- Departments of Cardiology, Kanazawa Medical University
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Background Syndrome X has been recognized as a disease that is primarily reflected in the cardiac microvasculature. Myocardial metabolism in this condition has been studied, but not in relation to small vessel pathology. Methods and Results In order to examine the relationship between myocardial metabolism and small vessel pathology, 24 consecutive patients with syndrome X (7 men, 17 women; mean age 58 years) were evaluated by the thallium exercise stress test, positron emission tomography using F-18 fluoro-deoxyglucose (FDG), and an endomyocardial biopsy. All patients showed either diffuse or focal increase in the myocardial uptake of FDG, but only 17 patients (71%) showed hypoperfused areas with partial or complete redistribution in the thallium study. Quantification of myocardial FDG uptake revealed that the value in syndrome X patients was 10-fold higher than in controls (p<0.0001). Histopathological examination revealed that in syndrome X there is an extensive increase in smooth muscle cells and thickening of the vascular wall, even in capillary vessels, and the small vessel lumen was markedly narrowed. There was a significant inverse correlation between FDG myocardial uptake and the microvessel luminal area. Conclusions In syndrome X patients, myocardial FDG uptake is increased extensively, which is strongly associated with narrowed myocardial microvasculature. (Circ J 2004; 68: 220 - 226)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 68 (3), 220-226, 2004
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680080146688
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- NII論文ID
- 110002667512
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
- http://id.crossref.org/issn/13469843
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- PubMed
- 14993776
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可