Action of FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by Chromobacterium violaceum No. 968, on Ha-ras Transformed NIH3T3 Cells.

• Ueda Hirotsugu

• Nakajima Hidenori

• Hori Yasuhiro

• Goto Toshio

• Okuhara Masakuni

Bibliographic Information

Other Title

• Action of FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by<i>Chromo-bacterium violaceum</i>No. 968, on Ha-<i>ras</i>Transformed NIH3T3 Cells

Abstract

FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and inhibited their growth. The reduction of c-myc expression was observed in FR901228-treated Ras-1 cells by RNA dot-blot hybridization. This reduction of c-myc expression and morphological reversion of the transformed cells to normal were correlated with growth inhibition (G₀/G₁ arrest in cell cycle).

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 58 (9), 1579-1583, 1994

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• Organic Chemistry
• Molecular Biology
• Applied Microbiology and Biotechnology
• General Medicine
• Biochemistry
• Analytical Chemistry
• Biotechnology

Details

• CRID: 1390001206473468160
• NII Article ID: 110002677153
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.58.1579
• ISSN: 13476947
• ISSN: 09168451
• PubMed: 7765477
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.58.1579
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed