Identification of the Modified Structure of Arginine Residues in Proteins with 3-Deoxyglucosone, a Maillard Reaction Intermediate.

• Hayase Fumitaka

• Konishi Yutaka

• Kato Hiromichi

抄録

The major compounds formed from the N^α-benzoylarginine amide (BzArgNH₂) and 3-deoxyglucosone (3DG) reaction system were purified by reversed-phase HPLC. The major product was identified as R-4-imidazolone (I) ; R=2-(4-benzoylamino-5-pentamide)amino-5-(2, 3, 4-trihydroxybutyl) as described in a previous paper (ref. 10). Intermediate products to the formation of compound I were identified as R-4(5H)-imidazolone (II), R-4(5-hydroxy)-imidazolone (III), and R-4-dihydroxyl-2-imidazoline (IV). Periodical changes in the amounts of compounds I, II, III, and IV suggest the formation of compound I via compound II by dehydration and oxidation from the BzArgNH₂-3DG reaction system to be the major pathway, the formation of compound I via compound III being the other pathway.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 59 (8), 1407-1411, 1995

  公益社団法人 日本農芸化学会

キーワード

• Organic Chemistry
• Molecular Biology
• Applied Microbiology and Biotechnology
• General Medicine
• Biochemistry
• Analytical Chemistry
• Biotechnology

詳細情報

• CRID: 1390001206471876352
• NII論文ID: 110002677664
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.59.1407
• COI: 1:CAS:528:DyaK2MXnvFKnur0%3D
• ISSN: 13476947
• ISSN: 09168451
• ISSN: http://id.crossref.org/issn/09168451
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.59.1407
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可