Synthesis of Amino Acid Derivatives of Kojic Acid and Their Tyrosinase Inhibitory Activity..

• Kobayashi Yoshikane

• Kayahara Hiroshi

• Tadasa Koji

• Nakamura Toshiko

• Tanaka Hiroshi

Abstract

Six N-carbobenzozy amino acid derivatives of kojic acid were synthesized to improve the tyrosinase inhibitory activity of kojic acid. All derivatives showed stronger activities than kojic acid. Among them, the L-phenylalanine derivative was the strongest inhibitor and its IC₅₀ value was about 1/80 that for kojic acid. Theinhibition mechanism of these derivatives is considered to be a noncompetitive one similar to that of kojic acid.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 59 (9), 1745-1746, 1995

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• Organic Chemistry
• Molecular Biology
• Applied Microbiology and Biotechnology
• General Medicine
• Biochemistry
• Analytical Chemistry
• Biotechnology

Details

• CRID: 1390001206474911488
• NII Article ID: 110002677741
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.59.1745
• COI: 1:CAS:528:DyaK2MXosFShtL4%3D
• ISSN: 13476947
• ISSN: 09168451
• ISSN: http://id.crossref.org/issn/09168451
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.59.1745
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed