Nitrile Hydratase and Its Application to Industrial Production of Acrylamide.

• YAMADA Hideaki

• KOBAYASHI Michihiko

抄録

Nitrile hydratase (NHase) was discovered in our laboratory. This enzyme was purified and characterized from various microorganisms. NHases are roughly classified into two groups according to the metal involved: Fe-type and Co-type. NHases are expected to have great potential as catalysts in organic chemical processing because they can convert nitriles to the corresponding higher-value amides under mild conditions. We have used microbial enzymes for the production of useful compounds; NHase has been used for the industrial production (production capacity: 30, 000 tons/year) of acrylamide from acrylonitrile. This is the first successful example of a biotransformation process for the manufacture of a commodity chemical. This review summarizes the history of NHase studied not only from a basic standpoint but also from an applied point of view.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 60 (9), 1391-1400, 1996

  公益社団法人 日本農芸化学会

キーワード

• nitrile
• nitrile hydratase
• acrylamide
• amidase
• nitrilase

詳細情報

• CRID: 1390001206473429120
• NII論文ID: 110002678273
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.60.1391
• COI: 1:CAS:528:DyaK28XlvFanurs%3D
• ISSN: 13476947
• ISSN: 09168451
• ISSN: http://id.crossref.org/issn/09168451
• PubMed: 8987584
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60.1391
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可