The Effects of Niacin on DNA Repair after N-Methyl-N′-nitro-N-nitrosoguanidine Treatment in Normal Human Lymphocytes

• OGATA Shin

• OKUMURA Katsuzumi

• TAGUCHI Hiroshi

書誌事項

タイトル別名

• The Effects of Niacin on DNA Repair after N-Methyl-N'-nitro-N-nitrosoguanidine Treatment in Normal Human Lymphocytes.
• Effects of Niacin on DNA Repair after N
• The Effects of Niacin on DNA Repair after<i>N</i>-Methyl-<i>N′</i>-nitro-<i>N</i>-nitrosoguanidine Treatment in Normal Human Lymphocytes

抄録

We have investigated the effects of niacin on NAD levels and on DNA repair in human lymphocytes. When lymphocytes were incubated in culture medium with various concentrations of niacin, incubation of lymphocytes with nicotinic acid at 5μM or nicotin-amide at 10 mM caused a 2-3 fold increase in NAD content. Under these conditions lymphocytes were treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), Interestingly, the rejoining of DNA strand breaks was promoted by nicotinic acid but nicotinamide inhibited the rejoining.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 61 (12), 2116-2118, 1997

  公益社団法人 日本農芸化学会

キーワード

• niacin
• DNA repair
• human lymphocytes
• poly(ADP-ribose)polymcrase
• N-methyl-N'-nitro-N-nitro soguanidine

詳細情報

• CRID: 1390282681450453248
• NII論文ID: 110002678892
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.61.2116
• COI: 1:CAS:528:DyaK1cXltFSksg%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 4406203
• PubMed: 9438992
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4406203
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.61.2116
• Web Site: https://search.jamas.or.jp/link/ui/1998108215
• 本文言語コード: en
• データソース種別:
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