Immunopotentiating Activity of Nigerooligosaccharides for the T Helper 1-Like Immune Response in Mice.

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  • MUROSAKI Shinji
    Research & Development Section, Takeda Food Products Ltd.
  • MUROYAMA Koutarou
    Research & Development Section, Takeda Food Products Ltd.
  • YAMAMOTO Yoshihiro
    Research & Development Section, Takeda Food Products Ltd.
  • KUSAKA Hiroaki
    Research & Development Section, Takeda Food Products Ltd.
  • LIU Tiei
    Laboratory of Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine
  • YOSHIKAI Yasunobu
    Laboratory of Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine

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  The immunopotentiating activity of nigerooligosaccharides (NOS), a mixture of nigerose, nigerosyl glucose and nigerosyl maltose, was studied in vitro and in vivo in mice. Mitogen-induced proliferation of splenocytes from normal mice was augmented in a dose-dependent manner by nigerose of NOS. NOS enhanced interleukin 12 (IL-12) and interferon-γ (IFN-γ) production by normal splenocytes in the presence of the potent IL-12 inducer, heat-killed Lactobacillus plantarum L-137, in vitro. Consistent with the in vitro finding, L. plantarum L-137-induced IL-12 production and IL-2-induced IFN-γ production were augmented in mice fed with a 14.6% NOS diet for 2 weeks compared with mice fed with a control diet. Notably, mice fed with the NOS diet showed significantly longer survival time than the control mice after the induction of an endogenous infection by administering 5-fluorouracil in a lethal dose. Taken together, these results suggest that NOS may exert immunopotentiating activity through the activation of an IL-12-dependent T helper 1-like immune response.<br>

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