Protective Effects of Dietary Nasunin on Paraquat-induced Oxidative Stress in Rats

    • KIMURA Yuriko
    • Department of Bioresourse Engineering, Faculty of Agriculture, Yamagata University
    • ARAKI Yumi
    • Department of Bioresourse Engineering, Faculty of Agriculture, Yamagata University
    • TAKENAKA Asako
    • Department of Bioresourse Engineering, Faculty of Agriculture, Yamagata University
    • IGARASHI Kiharu
    • Department of Bioresourse Engineering, Faculty of Agriculture, Yamagata University

Abstract

The preventive effects of nasunin (delphinidin-3-[4-p-coumaroyl-rhamnosyl (1→6) glucoside]-5-glucoside) on paraquat-induced oxidative stress were determined in rats. Decreased food intake and body weight gain and increased lung weight by feeding the rats a diet containing paraquat were clearly suppressed by supplementing nasunin to the paraquat diet. Paraquat feeding increased the concentration of thiobarbituric acid-reactive substances (TBARS) in liver lipids and the atherogenic index, and decreased the liver triacylglycerol level. These effects were also suppressed by supplementing nasunin to the paraquat diet. In addition, catalase activity in the liver mitochondrial fraction was markedly decreased by feeding the paraquat diet, this decrease being partially suppressed by supplementing the paraquat diet with nasunin. These results suggest that nasunin acted preventively against the oxidative stress in vivo that may have been due to active oxygen species formed through the action of paraquat.

Journal

Bioscience, biotechnology, and biochemistry   [List of Volumes]

Bioscience, biotechnology, and biochemistry 63(5), 799-804, 1999-05-23  [Table of Contents]

Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  37

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Cited by:  6

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Codes

  • NII Article ID (NAID) :
    110002679567
  • NII NACSIS-CAT ID (NCID) :
    AA10824164
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    09168451
  • NDL Article ID :
    4743739
  • NDL Source Classification :
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-G223
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE 

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