Non-effect of Hexamethonium, a Ganglionic Blocker, on the Response of Ileal Apolipoprotein A-4 mRNA Following a Massive Small Bowel Resection in Rats

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  • SONOYAMA Kei
    Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
  • FUJIWARA Reiko
    Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
  • KASAI Takanori
    Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

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  • Non-effect of Hexamethonium, a Ganglionic Blocker, on the Response of Ileal Apolipoprotein A-IV mRNA Following a Massive Small Bowel Resection in Rats

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  An intravenous infusion of hexamethonium, a ganglionic blocker, did not affect the increase in the apolipoprotein A-IV mRNA level in the residual ileum following a massive small bowel resection in unrestrained conscious rats. The result suggests that upregulation of the apolipoprotein A-IV gene in the residual ileum is not mediated by a neural pathway, including the nicotinic synapse route.<br>

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