Effects of 2,3-Diketo-L-gulonic Acid on the Oxidation of Yolk Lipoprotein.

• LI Meihua

  Institute of Environmental Science for Human Life, Ochanomizu University

• SUZUKI Emiko

  Department of Human Biological Studies, Ochanomizu University

• KURATA Tadao

  Institute of Environmental Science for Human Life, Ochanomizu University

抄録

2,3-Diketo-L-gulonic acid (DKG) is an important intermediate product of oxidative degradation of L-ascorbic acid (AsA) in both biological and food systems, but the physiological function of DKG is still unclear. In this study, it was found that DKG had a strong antioxidative effect on copper-dependent oxidative modification of yolk lipoprotein (YLP), on the basis of both the decreased electrophoretic mobility and longer lag time of conjugated diene formation in a concentration-dependent manner. DKG is known to be very unstable and easily converts into two δ-lactones of DKG, the 3,4-enediol form of DKG δ-lactone (3,4-DKGL) and 2,3-enediol form of DKG δ-lactone (2,3-DKGL) depending on both pH and temperature. 3,4-DKGL was thought to be the first degradation product of DKG and could play an antioxidative role in the oxidation of lipoproteins induced by copper ion or peroxyl radicals in neutral aqueous solution.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 65 (3), 599-604, 2001

  公益社団法人 日本農芸化学会

キーワード

• 2,3-diketo-L-gulonic acid
• 3,4-enediol or 2,3-enediol form of DKG δ-lactones
• copper
• oxidized YLP

詳細情報

• CRID: 1390282681450500992
• NII論文ID: 110002680309
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.65.599
• COI: 1:CAS:528:DC%2BD3MXisFKqurw%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 5737807
• PubMed: 11330674
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5737807
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.65.599
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可