Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B.

• TOGASHI Ken-ichi

  Antibiotics Laboratory, RIKEN Present address: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo

• KO Hack-Ryong

  Antibiotics Laboratory, RIKEN Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology

• AHN Jong-Seog

  Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology

• OSADA Hiroyuki

  Antibiotics Laboratory, RIKEN

抄録

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 65 (3), 651-653, 2001

  公益社団法人 日本農芸化学会

キーワード

• screening
• telomerase
• CRM646-A
• thielavin B
• reverse transcriptase

詳細情報

• CRID: 1390001206473784704
• NII論文ID: 110002680317
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.65.651
• COI: 1:CAS:528:DC%2BD3MXisFKqu74%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 5738054
• PubMed: 11330682
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5738054
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.65.651
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可