Soybean Resistant Proteins Interrupt an Enterohepatic Circulation of Bile Acids and Suppress Liver Tumorigenesis Induced by Azoxymethane and Dietary Deoxycholate in Rats.

• KANAMOTO Ryuhei

  Department of Biological Resource Chemistry, Kyoto Prefectural University

• AZUMA Naoyuki

  Department of Biological Resource Chemistry, Kyoto Prefectural University

• MIYAMOTO Tomokazu

  Department of Biological Resource Chemistry, Kyoto Prefectural University

• SAEKI Tohru

  Department of Biological Resource Chemistry, Kyoto Prefectural University

• TSUCHIHASHI Yasunari

  Hospital Department of Pathology, Kyoto Prefectural University of Medicine

• IWAMI Kimikazu

  Department of Biological Resource Chemistry, Kyoto Prefectural University

抄録

We found that azoxymethane and dietary deoxycholate induced liver tumors in rats. The incidence and the development of the tumor were closely related to the enterohepatic circulation of bile acids. The feeding of a high-molecular-weight fraction of soy protein digest (HMF) suppressed the tumorigenesis, probably due to the inhibitory effect of soybean resistant protein on reabsorption of bile acids in the intestine.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 65 (4), 999-1002, 2001

  公益社団法人 日本農芸化学会

キーワード

• soybean resistant proteins
• bile acid
• enterohepatic circulation
• colon tumorigenesis
• liver tumorigenesis

詳細情報

• CRID: 1390282681452705920
• NII論文ID: 110002680384
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.65.999
• COI: 1:CAS:528:DC%2BD3MXjsVagtL4%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 5769497
• PubMed: 11388492
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5769497
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.65.999
• Web Site: https://search.jamas.or.jp/link/ui/2001263878
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可