Fused Heterocyclic Antioxidants: Antioxidative Activities of Hydrocoumarins in a Homogeneous Solution.

  • NISHIYAMA Tomihiro
    Department of Applied Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University
  • OHNISHI Junichi
    Department of Applied Chemistry, Faculty of Engineering, Kansai University
  • HASHIGUCHI Yasuhiro
    Department of Applied Chemistry, Faculty of Engineering, Kansai University

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We compared the antioxidative activities of seven hydrocoumarins with those of α-tocopherol for the oxidation of tetralin and linoleic acid in a homogeneous solution. Hydrocoumarins exhibited a higher induction period than that of α-Toc in both systems. However, the rate of oxygen absorption during the induction period for α-Toc was slower than that of the hydrocoumarins in both systems. In addition, 6,7-dihydroxy-4,4-dimethylhydrocoumarin showed less cytotoxicity toward human fibroblasts than did 2,6-di-t-butyl-4-methylphenol.

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