Regioselectivity in Sulfation of Galactosides by Sulfuric Acid and Dicyclobexylcarbodi-imide

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  • Regioselectivity in Sulfation of Galactosides by Sulfuric Acid and Dicyclohexylcarbodi-imide.

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Methyl α-and β-D-galactopyranosides and 4-O-β-D-galactopyranosyl-3, 6-anhydro-L-galactose dimethylacetal were sulfated with sulfuric acid and dicyclohexylcarbodi-imide as a condensation reagent. The sulfated sugars were isolated by ion-exchange chromatography, characterized, and assigned by methylation analyses. On the basis of the yield of each sulfated product that was isolated, sulfation on O-6 appeared to be predominant.

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