Clinical Value of Iodine-123 Beta-Methyliodophenyl Pentadecanoic Acid (BMIPP) Myocardial Single Photon Emission Computed Tomography for Predicting Cardiac Death Among Patients With Chronic Heart Failure

• Sasaki Ryu

  Division of Cardiology, Fujisawa Municipal Hospital

• Mitani Isao

  Second Department of Internal Medicine, Yokohama City University School of Medicine

• Usui Takashi

  Division of Cardiology, Fujisawa Municipal Hospital

• Kitamura Yutaka

  Division of Cardiology, Yokosuka Municipal Hospital

• Yoshii Yuzuru

  Division of Cardiology, Saiseikai Yokohama Nanbu Hospital

• Ishikawa Toshiyuki

  Second Department of Internal Medicine, Yokohama City University School of Medicine

• Uchino Kazuaki

  Second Department of Internal Medicine, Yokohama City University School of Medicine

• Takahashi Nobukazu

  Second Department of Internal Medicine, Yokohama City University School of Medicine

• Kimura Kazuo

  Second Department of Internal Medicine, Yokohama City University School of Medicine

• Umemura Satoshi

  Second Department of Internal Medicine, Yokohama City University School of Medicine

抄録

In the present study, the effectiveness of ¹²³I-β-methyliodophenyl pentadecanoic acid (BMIPP) single photon emission computed tomography (SPECT) for predicting cardiac death of patients with chronic heart failure was evaluated. Abnormalities of fatty acid metabolism are found in patients with chronic heart failure and BMIPP was developed as a tracer for scintigraphic assessment of myocardial fatty acid utilization. The study group comprised 74 patients with chronic heart failure with a left ventricular ejection fraction (LVEF) <45% on left ventriculography or radionuclide angiocardiography. They underwent both ²⁰¹Tl SPECT and BMIPP SPECT. The uptake of tracer was scored semiquantitatively from 0 (normal) to 4 (defect) in 20 segments and a total defect score (TDS) for all 20 segments was calculated. On planar images the mediastinum to heart count ratio (H/M) was calculated for the BMIPP and Tl studies, and the H/M_BMIPP:H/M_Tl (H/M_BMIPP divided by H/M_Tl) was also calculated. The mean follow-up period was 660 days and there were 17 cases of cardiac death. Multivariate analysis identified H/M_BMIPP:H/M_Tl (p<0.05) and LVEF (p<0.05) as independent predictors of cardiac death. The receiver-operating characteristic curve of H/M_BMIPP:H/M _Tl was situated to the left relative to LVEF. Analysis of the myocardial metabolism by BMIPP SPECT can predict the high-risk patients with chronic heart failure. (Circ J 2003; 67: 918 - 924)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 67 (11), 918-924, 2003

  一般社団法人 日本循環器学会

キーワード

• Fatty acid metabolism
• Heart failure
• Nuclear cardiology

詳細情報

• CRID: 1390282680081740672
• NII論文ID: 110002692119
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.67.918
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 14578597
• Web Site: http://www.jstage.jst.go.jp/article/circj/67/11/67_11_918/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004111778
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可