In Normoglycemic Koreans, Insulin Resistance and Adipocity are Independently Correlated With High Blood Pressure

DOI Web Site PubMed 被引用文献2件 参考文献50件
  • Sung Ki Chul
    Divisions of Cardiology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Kim Byung Jin
    Divisions of Cardiology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Kim Bum Su
    Divisions of Cardiology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Kang Jin Ho
    Divisions of Cardiology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Lee Man Ho
    Divisions of Cardiology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Park Jung Roe
    Divisions of Cardiology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Rhee Eun Jung
    Endocrinology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Lee Won Young
    Endocrinology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Kim Sun Woo
    Endocrinology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Kim Hyang
    Nephrology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Lee Kyu Beck
    Nephrology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital
  • Ryu Seung Ho
    Occupational medicine, Department of Internal Medicine, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital

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Background There is some controversy about the role of insulin resistance (IR) in the regulation of blood pressure (BP). Moreover, a large study of the association between BP and IR has not been conducted in normal glucose tolerance Asians. The present study investigated the relationships between IR, body mass index (BMI) and waist circumference and BP in normoglycemic Koreans. Methods and Results Anthropometric indices of adiposity, metabolic variables (fasting serum insulin and a homeostasis model assessment (HOMA) index of insulin sensitivity), BP and several cardiovascular risk factors were measured during a cross-sectional survey of 49,076 normoglycemic Korean subjects. A high BP was defined as a systolic BP ≥140 mmHg or a diastolic BP ≥90 mmHg. The prevalence of high BP by HOMA grading was 0.985 (95% confidence interval (CI) 0.857-1.132, p=0.835), 1.180 (95% CI 1.032-1.350, p=0.016), 1.289 (95% CI 1.129-1.472, p<0.001), and 1.540 (95% CI 1.341-1.768, p<0.001) times higher in subjects in the second, third, fourth, and fifth quintiles, respectively, compared with those in the first quintile. In addition, age, sex, waist circumference and BMI were found to be significantly associated with a high BP. Conclusion IR, BMI and waist circumference are independently correlated with high BP in normoglycemic Koreans. (Circ J 2004; 68: 898 - 902)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 68 (10), 898-902, 2004

    一般社団法人 日本循環器学会

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