Insecticidal and Neural Activities of Candidate Photoaffinity Probes for Neonicotinoid Binding Sites
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- MATSUDA Kazuhiko
- Department of Agricultural Chemistry, Kinki University
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- IHARA Makoto
- Department of Agricultural Chemistry, Kinki University
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- NISHIMURA Keiichiro
- Research Institute for Advanced Science and Technology, Osaka Prefecture University
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- SATTELLE David B.
- MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford
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- KOMAI Koichiro
- Department of Agricultural Chemistry, Kinki University
書誌事項
- タイトル別名
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- Insecticidal and Neural Activities of Candidate Photoaffinity Probes for Neonicotinoid Building Sites.
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Photoreactive derivatives of imidacloprid and its nitromethylene analogue were synthesized as candidate photoaffinity probes for identifying the amino acid residues of nicotinic acetylcholine receptors (nAChRs) that interact with the neonicotinoid insecticides. When the candidate probes were injected into American cockroaches, the nerve cord neural activity initially increased, then ceased and death of the insect followed. Both the nerve cord and toxicity were enhanced by changing the photoreactive substituent from the para position to the meta position on the spacer benzyl moiety. When tested on a Drosophila SAD/chicken β2 hybrid, recombinant nAChR expressed in Xenopus oocytes, the nitromethylene candidate probes showed agonist activity similar to that previously observed for imidacloprid.
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 65 (7), 1534-1541, 2001
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681451865856
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- NII論文ID
- 110002693374
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3MXlvVSmsb0%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 5862349
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- PubMed
- 11515536
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可