Antimutagenicity of Mono-, Di-, and Tricaffeoylquinic Acid Derivatives Isolated from Sweetpotato (<i>Ipomoea batatas</i>L.) Leaf

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  • YOSHIMOTO Makoto
    <i>Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region</i>
  • YAHARA Shoji
    <i>Graduate School of Pharmaceutical Sciences, Kumamoto University</i>
  • OKUNO Shigenori
    <i>Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region</i>
  • ISLAM Md. Shahidul
    <i>Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region</i>
  • ISHIGURO Koji
    <i>Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region</i>
  • YAMAKAWA Osamu
    <i>Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region</i>

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  • Antimutagenicity of Mono-, Di-, and Tricaffeoylquinic Acid Derivatives Isolated from Sweetpotato (Ipomoea batatas L.) Leaf.

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  The caffeoylquinic acid derivatives, 3-mono-O-caffeoylquinic acid (chlorogenic acid, ChA), 3,4-di-O-caffeoylquinic acid (3,4-diCQA), 3,5-di-O-caffeoylquinic acid (3,5-diCQA), 4,5-di-O-caffeoylquinic acid (4,5-diCQA) and 3,4,5-tri-O-caffeoylquinic acid (3,4,5-triCQA), and caffeic acid (CA) were isolated from the sweetpotato (Ipomoea batatas L.) leaf. We examined the antimutagenicity of these caffeoylquinic acid compounds to promote new uses of the sweetpotato leaf. These caffeoylquinic acid derivatives effectively inhibited the reverse mutation induced by Trp-P-1 on Salmonella typhimurium TA 98. The antimutagenicity of these derivatives was 3,4,5-triCQA>3,4-diCQA=3,5-diCQA=4,5-diCQA>ChA in this order. There was no difference in the antimutagenicity of all dicaffeoylquinic acid derivatives. A comparison of the activities and structures of these compounds suggested that the number of caffeoyl groups bound to quinic acid played a role in the antimutagenicity of the caffeoylquinic acid derivatives. The sweetpotato leaves contained distinctive polyphenolic components with a high content of mono-, di-, and tricaffeoylquinic acid derivatives and could be a source of physiological functions.<br>

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