Biotransformation of (−)-Verbenone by Human Liver Microsomes

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  • MIYAZAWA Mitsuo
    <i>Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University</i>
  • SUGIE Atsushi
    <i>Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University</i>
  • SHINDO Masaki
    <i>Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University</i>

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  • Biotransformation of (-)-Verbenone by Human Liver Microsomes.

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  The biotransformation of (−)-verbenone was investigated with human liver microsomes by using GC-MS. Regioselective biotransformation was observed when (−)-verbenone was incubated with the liver microsomes. (−)-10-Hydroxyverbenone was formed from (−)-verbenone of kinetic analysis showed that the Km and Vmax values for the hydroxylation of (−)-verbenone by liver microsomes from three human samples, HG-70, HG-56 and HG-23, were 1.1 mM and 4.8 nmol/min/nmol P450, 0.6 mM and 2.1 nmol/min/nmol P450, and 2.8 mM and 4.6 nmol/min/nmol P450, respectively.<br>

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