Inhibition of Chromosome Separation in Fertilized Starfish Eggs by Kalihinol F, a Topoisomerase 1 Inhibitor Obtained from a Marine Sponge
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- OHTA Emi
- <i>Instrument Center for Chemical Analysis, Hiroshima University</i> <i>Department of Applied Biochemistry, Hiroshima University</i>
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- OHTA Shinji
- <i>Instrument Center for Chemical Analysis, Hiroshima University</i>
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- HONGO Tomokatsu
- <i>Department of Applied Biochemistry, Hiroshima University</i>
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- HAMAGUCHI Yukihisa
- <i>Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology</i>
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- ANDOH Toshiwo
- <i>Department of Bioengineering, Faculty of Engineering, Soka University</i>
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- SHIODA Masaki
- <i>Department of Biological Science, Faculty of Science, Kumamoto University</i>
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- IKEGAMI Susumu
- <i>Instrument Center for Chemical Analysis, Hiroshima University</i> <i>Department of Applied Biochemistry, Hiroshima University</i>
書誌事項
- タイトル別名
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- Inhibition of Chromosome Separation in Fertilized Starfish Eggs by Kalihinol F, a Topoisomerase I Inhibitor Obtained from a Marine Sponge
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Kalihinol F, a naturally occurring diterpene from a marine sponge, Acanthella sp., inhibited chromosome separation in fertilized starfish (Asterina pectinifera) eggs but allows the first cleavage to occur, thereby forming unseparated metaphase chromosomes which were elongated between the two daughter cells. The chromosomes were eventually torn off in the embryonic cells. Most of the cells gradually lost the chromosomes during the cell cycle progression. The embryonic development halted at the morula stage just before the onset of blastulation. The mitotic failure occurred when kalihinol F was applied to a fertilized egg during the second meiotic process, but not after the completion of the second meiotic division. Kalihinol F inhibited topoisomerase I activity in vitro, but had no effects on activities of DNA polymerases α, β, and γ, and of topoisomerase II. These results suggest that the topoisomerase I plays an essential role in meiosis II in this species.<br>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 67 (11), 2365-2372, 2003
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681452791680
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- NII論文ID
- 110002693986
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 6770605
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- PubMed
- 14646195
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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- 使用不可