Quantification of .ALPHA.-Methylene-.GAMMA.-butyrolactone Extracted from Different Parts of Alstroemeria wilhelmina and Evaluation of it's Antigenicity Using the Guinea-Pig Maximization Test.
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- HARADA Koichi
- Department of Hygiene, Kumamoto University School of Medicine
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- OHMORI Shoko
- Department of Hygiene, Kumamoto University School of Medicine
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- WEI Chang-Nian
- Kumamoto Total Institute of Fitness
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- ARIMATSU Yoshiki
- Ginkyo College of Medical Science
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- UEDA Atsushi
- Department of Hygiene, Kumamoto University School of Medicine
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To detect the type of contact dermatitis caused due to the handling of Alstroemeria wilhelmina, 1% α-methylene-γ-butyrolactone (α-MBL) dissolved in physiological saline and a five-fold diluted saline solution of original extracts of flowers, leaves and stems of the flower were applied to guinea-pigs for induction treatment, and 0.1% α-MBL physiological saline and a ten-fold diluted solution of the original extracts were applied to the animals as the challenge treatment in compliance with the guinea-pig maximization test (GMT). As a consequence, not only primary irritant dermatitis was observed, but also delayed type allergic contact dermatitis due to Alstroemeria wilhelmina was observed. α-MBL determined in the extracts using high-performance liquid chromatography (HPLC) was found to be the biochemical material cause of the contact dermatitis. The flower region contained α-MBL in the highest concentrations compared with those of the leaves and stems. Therefore, the quantification of α-MBL in the extracts was concluded as being a useful evaluating method for contact dermatitis due to the handling of Alstroemeria.
収録刊行物
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- Environmental Health and Preventive Medicine
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Environmental Health and Preventive Medicine 6 (4), 229-234, 2002
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詳細情報 詳細情報について
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- CRID
- 1390282679435451520
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- NII論文ID
- 110002694749
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- NII書誌ID
- AA1108348X
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- COI
- 1:CAS:528:DC%2BD38Xis1aqsLk%3D
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- ISSN
- 13474715
- 1342078X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 使用不可