Association of Inflammatory Marker and Highly Sensitive C-Reactive Protein With Aerobic Exercise Capacity, Maximum Oxygen Uptake and Insulin Resistance in Healthy Middle-Aged Volunteers Kondo Noriyasu Nomura Masahiro Nakaya Yutaka Ito Susumu Ohguro Takashi 社団法人日本循環器学会 Circulation journal : official journal of the Japanese Circulation Society 13469843 69 4 452 457 2005-03-20 Background Increased levels of inflammation markers, such as C-reactive protein (CRP) and tumor necrosis factor-α, have been found in insulin resistance syndrome. Those with elevated levels of high-sensitive CRP (hs-CRP) are at a higher risk for coronary heart disease. In the present study, we evaluated whether maximum oxygen uptake and insulin resistance are related to hs-CRP for the primary prevention of coronary heart disease. Methods and Results The subjects were 50 subjects who did not have diabetes mellitus. A multi-step treadmill exercise test was performed to obtain the maximum oxygen uptake when assessed by computerized breath-by-breath analysis. As an index of insulin resistance, the homeostasis model insulin resistance index (HOMA-R ; fasting glucose×fasting insulin/405) was used. In addition, bodyweight, body mass index, subcutaneous fat thickness, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride were measured. Multivariate analysis revealed that hs-CRP was significantly correlated with HDL-cholesterol, uric acid, γ-glutamyl transpeptidase and maximum oxygen uptake. The maximum oxygen uptake showed the smallest odds ratio was in terms of the relationship with hs-CRP. Conclusions The present study suggests that the development of exercising habits increases the maximum oxygen uptake. Furthermore, an elevated maximum oxygen uptake decreases HOMA-R and reduces the inflammatory marker CRP, suggesting that exercising habit plays an important role in the primary prevention of coronary heart disease. 2005-03-20 110002696120 AA11591968 ENG CJP CJPref NII-ELS J-STAGE 3 28 11 Association of Inflammatory Marker and Highly Sensitive C-Reactive Protein With Aerobic Exercise Capacity, Maximum Oxygen Uptake and Insulin Resistance in Healthy Middle-Aged Volunteers Kondo Noriyasu Nomura Masahiro Nakaya Yutaka Ito Susumu Ohguro Takashi Japanese Circulation Society Circulation journal : official journal of the Japanese Circulation Society Background Increased levels of inflammation markers, such as C-reactive protein (CRP) and tumor necrosis factor-α, have been found in insulin resistance syndrome. Those with elevated levels of high-sensitive CRP (hs-CRP) are at a higher risk for coronary heart disease. In the present study, we evaluated whether maximum oxygen uptake and insulin resistance are related to hs-CRP for the primary prevention of coronary heart disease. Methods and Results The subjects were 50 subjects who did not have diabetes mellitus. A multi-step treadmill exercise test was performed to obtain the maximum oxygen uptake when assessed by computerized breath-by-breath analysis. As an index of insulin resistance, the homeostasis model insulin resistance index (HOMA-R ; fasting glucose×fasting insulin/405) was used. In addition, bodyweight, body mass index, subcutaneous fat thickness, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride were measured. Multivariate analysis revealed that hs-CRP was significantly correlated with HDL-cholesterol, uric acid, γ-glutamyl transpeptidase and maximum oxygen uptake. The maximum oxygen uptake showed the smallest odds ratio was in terms of the relationship with hs-CRP. Conclusions The present study suggests that the development of exercising habits increases the maximum oxygen uptake. Furthermore, an elevated maximum oxygen uptake decreases HOMA-R and reduces the inflammatory marker CRP, suggesting that exercising habit plays an important role in the primary prevention of coronary heart disease. Kondo Noriyasu Department of Health Examination, Kochi Red Cross Hospital Nomura Masahiro Department of Digestive and Cardiovascular Medicine Nakaya Yutaka Department of Nutrition and Metabolism University of Tokushima Graduate School Ito Susumu Department of Digestive and Cardiovascular Medicine Ohguro Takashi Department of Health Examination, Kochi Red Cross Hospital