Relationship Between Serum Lipoprotein(a) Concentrations and Coronary Vasomotion in Coronary Spastic Angina

• Tsuchida Keiichi

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Hori Tomoyuki

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Tanabe Naohito

  Health Promotion, Graduate School of Medical and Dental Sciences, Niigata University

• Makiyama Yashiro

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Ozawa Takuya

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Saigawa Takashi

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Watanabe Ritsuo

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Tanaka Takayuki

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Nasuno Akimitsu

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Fukunaga Hiroshi

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Mezaki Tohru

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Nakamura Yuichi

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

• Aizawa Yoshifusa

  Divisions of Cardiology, Graduate School of Medical and Dental Sciences, Niigata University

抄録

Background Elevated lipoprotein(a) (Lp(a)) concentrations are reported to impair endothelium-dependent vasodilatation of the epicardial coronary artery. However, the effects on vasomotor abnormalities in coronary spastic angina (CSA) have not been thoroughly investigated. Methods and Results In the present study 80 sites of spasm (spastic sites) without significant organic stenosis (% diameter stenosis <50%) were assessed in 80 patients with CSA diagnosed by intracoronary ergonovine (EM) test. Spastic sites were divided into 2 groups: Group 1 included 30 sites provoked by the full dose (=50 μg) of EM, and Group 2 included 50 sites provoked with less than 50 μg (34.7±8.2 μg). Control subjects (n=22) did not show coronary spasm with the EM test. Serum Lp(a) concentrations were measured in all patients. Group 2 had a significantly greater basal coronary artery tone in the spastic sites than Group 1 (p<0.001). Lp(a) level in Group 2 was significantly higher compared with both the control group and Group 1 (p<0.05 by analysis of variance). Multivariate analysis confirmed that only serum Lp(a) concentration was associated with low-dose EM spasm provocation. Conclusions Serum Lp(a) concentration could be a marker for high disease activity in CSA. (Circ J 2005; 69: 521 - 525)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 69 (5), 521-525, 2005

  一般社団法人 日本循環器学会

キーワード

• Basal coronary artery tone
• Coronary spastic angina
• Ergonovine
• Lipoprotein(a)

詳細情報

• CRID: 1390001205104896256
• NII論文ID: 110002696134
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.69.521
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 15849436
• Web Site: http://www.jstage.jst.go.jp/article/circj/69/5/69_5_521/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006262507
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可