PEG-Inhibitor Conjugates: Application of Diphenyl α-Aminoalkylphosphonate to Removal of Chymotrypsin

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  • UMEZAKI Makiko
    <i>Department of Material Systems Engineering and Life Science, Faculty of Engineering, Toyama University</i>
  • FUJII Takayoshi
    <i>Department of Material Systems Engineering and Life Science, Faculty of Engineering, Toyama University</i>
  • YOSHIMURA Toshiaki
    <i>Department of Material Systems Engineering and Life Science, Faculty of Engineering, Toyama University</i>
  • YAMAZAKI Isao
    <i>Yayoi Kagaku Kogyo Co., Ltd.</i>
  • ONO Shin
    <i>Department of Material Systems Engineering and Life Science, Faculty of Engineering, Toyama University</i>

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タイトル別名
  • PEG-Inhibitor Conjugates: Application of Diphenyl .ALPHA.-Aminoalkylphosphonate to Removal of Chymotrypsin
  • PEG Inhibitor Conjugates Application of Diphenyl アルファ Aminoalkylphosphonate to Removal of Chymotrypsin

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  Diphenyl 1-amino-2-phenylethylphosphonate was introduced to poly(ethylene glycol)s (PEGs) with average molecular masses of 300, 400, and 600 to prepare water-insoluble PEG-inhibitor conjugates. Interestingly, only the conjugate from PEG with an average molecular weight of 600 formed a precipitate with chymotrypsin but not with trypsin. The results demonstrated that the PEG-inhibitor conjugate is useful for separation of chymotrypsin.<br>

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