Effect of chondroitin sulfate and hyaluronic acid on gene expression in a three-dimensional culture of chondrocytes

• Nishimoto, Shohei

• Takagi, Mutsumi

• Wakitani, Shigeyuki

• Nihira, Takuya

• Yoshida, Toshiomi

抄録

The effect of glycosaminoglycan addition on a three-dimensional (3D) culture of porcine chondrocyte cells was investigated with a view to use in cartilage regenerative medicine. Chondroitin sulfate C increased the mRNA expression of type 2 collagen, while chondroitin sulfate A did not. Hyaluronic acid of high molecular weight markedly decreased the mRNA expression of both aggrecan and type 2 collagen, although hyaluronic acid of low molecular weight showed no apparent effect.

収録刊行物

• Journal of Bioscience and Bioengineering

  Journal of Bioscience and Bioengineering 100 (1), 123-126, 2005-07

  The Society for Biotechnology, Japan

キーワード

• chondrocyte
• chondroitin sulfate
• hyaluronic acid
• RT-PCR

詳細情報

• CRID: 1050001338980033536
• NII論文ID: 110002703755
• NII書誌ID: AA11307678
• ISSN: 13474421
• ISSN: 13891723
• HANDLE: 2115/14716
• NDL書誌ID: 7373248
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7373248
• Web Site: https://search.jamas.or.jp/link/ui/2006219739
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • NDL
  • CiNii Articles